電子郵件：shenxu@zhku.edu.cn

通訊地址：廣州海珠區仲恺路501号

教研室：動物遺傳育種與繁殖

簡介

沈栩，女，博士，副研究員。現為仲恺農業工程學院太阳成集团tyc234cc專任教師、“廣東省水禽健康養殖科技創新平台”骨幹成員。長期從事禽類功能基因組研究，重點研究禽類繁殖特性(季節性繁殖行為和就巢行為)的分子調控機制，先後承擔了多項與本項目相關的國家級和省 部級課題。

教育背景

2008-09 至 2011-06, 華南農業大學, 動物遺傳育種與繁殖, 博士

2005-09 至 2008-06, 華南農業大學, 動物遺傳育種與繁殖, 碩士

2001-09 至 2005-06, 華南農業大學, 動物科學, 學士

工作經曆

2021-01 至 今, 仲恺農業工程學院, 太阳成集团tyc234cc, 副研究員

2019-06 至 2020-12, 仲恺農業工程學院, 太阳成集团tyc234cc, 講師

2014-11 至 2019-06, 中山大學, 生命科學學院, 助理研究員

2011-10 至2014-10，中國科學院北京基因組研究所，博士後

主講課程

《分子生物學》 《細胞生物學》

研究領域

禽類功能基因組研究，重點圍繞禽類繁殖特性(季節性繁殖行為和就巢行為)相關的表觀遺傳調控機制。

承擔主要項目

1. 國家自然科學基金-青年項目： 轉錄因子NR5A1 介導的多基因調控網絡影響雞就巢性狀的遺傳和進化機制（31301010）, 2014/01-2016/12, 主持；

2. 中國博士後科學基金-面上項目：轉錄因子NR5A1和Egr1參與家雞繁殖性狀調控的分子機制（2012M520359），2012/09-2013/10，主持；

3. 廣州市科技計劃基礎與應用基礎研究項目：鵝下丘腦光周期應答基因的鑒定及其影響GnRH表達的分子調控機制（202102080162），2021/04-2024/03），主持；

4. 廣東省基礎與應用基礎研究基金-面上項目：光周期調控鵝垂體PT部thyrotroph細胞季節性分泌TSH的分子機制（2021A1515010781）, 2021/01- 2023/12,主持；

5. 廣東省重點建設學科科研能力提升項目:馬崗鵝下丘腦 MBH 區 tanycytes 細胞脫碘酶系統對光周期應答的表觀調控機制研究(2021ZDJS006), 2022/01-2024/12, 主持。

代表性論著

1. Jiaxin Liu#, Yanglong Xu#, Yushuai, Wang, Jinning, Zhang, Yuting Fu, Sui Liufu, Danli Jiang, Jianqiu Pan, Hongjia Ouyang, Yunmao Huang*, Yunbo Tian*, Xu Shen*. The DNA Methylation Status of the Serotonin Metabolic Pathway Associated with Reproductive Inactivation Induced by Long-Light Exposure in Magang geese. BMC Genomics, Accept.

2. Jun Tang, Hongjia Ouyang , Xiaomei Chen, Danli Jiang, Yunbo Tian, Yunmao Huang, Xu Shen. Comparative Transcriptome Analyses of Leg Muscle during Early Growth between Geese ( Anser cygnoides) Breeds Differing in Body Size Characteristics. Genes (Basel). 2023 May 7;14(5):1048.  doi: 10.3390/genes14051048.

3. Jianye Chang, Di Fan, Jiaxin Liu, Yanglong Xu, Xuefei Huang, Yunbo Tian, Jin Xu, Yunmao Huang, Jue Ruan*, Xu Shen*. Transcriptomic and Chromatin Landscape Analysis Reveals That Involvement of Pituitary Level Transcription Factors Modulate Incubation Behaviors of Magang Geese. Genes (Basel). 2023 Mar 28;14(4):815. doi: 10.3390/genes14040815.

4. Yanglong Xu, Danli Jiang, Jiaxin Liu , Yuting Fu, Yan Song, Di Fan, Xuefei Huang, Sui Liufu, Jianqiu Pan, Hongjia Ouyang, Yunbo Tian, Xu Shen*, Yunmao Huang*. Photoperiodic Changes in Both Hypothalamus Neurotransmitters and Circulating Gonadal Steroids Metabolomic Profiles in Relation to Seasonal Reproduction in Male Quail. Front Physiol. 2022 Mar 25;13:824228. doi: 10.3389/fphys.2022.824228. eCollection 2022.

5. Xu Shen, XueBai, Chenlong Luo, Danli Jiang, Xiujin Li, Xumeng Zhang, Yunbo Tian, Yunmao Huang. Quantitative proteomic analysis of chicken serum reveals key proteins affecting follicle development during reproductive phase transitions. Poultry Science, 2021,100(1):325-333. doi: 10.1016/j.psj.2020.09.058

6. Yuezheng Zhang#, Yawei Li#, Tao Li#, Xu Shen#, Tianqi Zhu, Yong Tao, Xueying Li, Di Wang,  Qin Ma, Zheng Hu, Jialin Liu, Jue Ruan, Jun Cai, Hurng-Yi Wang, Xuemei Lu. Genetic load and potential mutational meltdown in cancer cell populations.Molecular Biology and Evolution, 2019, 1;36(3):541-552. doi: 10.1093/molbev/msy231

7. Guangan Lu, Yixin Zhao, Hao Yang, Ao Lan, Suhua Shi, Zhongqi Liufu, Yao Huang, Tian Tang, Jin Xu, Xu Shen*, Chung-I Wu*. Death of new microRNA genes in Drosophila via gradual loss of fitness advantages. Genome Research. 2018, 28(9):1309-1318.

8. Shen Xu，Bai Xue，Xu Jin，Zhou Min，Xu Haipin，Nie Qinghua，Lu Xuemei ，Zhang Xiquan . Transcriptome sequencing reveals genetic mechanisms underlying the transition between the laying and brooding phases and gene expression changes associated with divergent reproductive phenotypes in chickens. Mol Biol Rep, 2016,43(9)：977~989.

9. Shen X , Zeng H, Xie L, He J, Li J, Xie X, Luo C, Xu H, Zhou M, Nie Q, Zhang X, The GTPase activating Rap/RanGAP domain-like 1 gene is associated with chicken reproductive traits. PLoS One. 2012,7(4):e33851.

10. Xu H # , Shen X # (Contributed), Zhou M, Fang M, Zeng H, Nie Q, Zhang X. The genetic effects of the dopamine D1 receptor gene on chicken egg production and broodiness traits. BMC Genet. 2010, 11:17.

專利及其他成果

張細權、沈栩、曾華、謝亮. 與雞 300 日齡産蛋量相關的 GARNL1 基因上的位點及其應用. 2012.12. 中國. ZL 2010 10280382.X

阮珏，王開樂，沈栩，呂雪梅，吳仲義. 一種DNA擴增方法. 2019.05.17. 中國，ZL 2014 10448896.X