趙麗娟
趙麗娟，女, 水産養殖專業，農學博士，
E-mail: zhaolijuan4234@163.com；
通信地址： 廣州市海珠區仲恺路501号仲恺農業工程學院太阳成集团tyc234cc；
郵編：510225
個人概述：
趙麗娟，現工作于仲恺農業工程學院太阳成集团tyc234cc，副教授。大學畢業于煙台大學，淡水養殖專業，随後在大連海洋大學獲得碩士學位，華中農業大學獲得博士學位，2014-2015年從事水産品質量安全檢測工作，于2016-2018年脫産從事博士後學習。大學畢業後，在山東省淡水漁業研究院工作，主要負責水産動物的繁殖育種、養殖和疾病防控以及國外優良品種的引進與培育，有8年的一線生産經驗。養殖對象主要包括羅非魚、淡水白鲳、巴沙魚、南美白對蝦、黃颡魚、海參、彩虹鲷、鳗鲡、史氏鲟、翹嘴紅鲌以及“四大家魚”等常見鯉科魚類、引進品種有淡水黑鲷、寶石鲈、俄羅斯鯉魚等。
科研方面自2005年攻讀碩士後一直從事水産營養、疾病與免疫學相關研究工作；2019年1月自山東省淡水漁業研究院調入仲恺農業工程學院。主持基金項目包括國家自然科學基金青年基金（31602190），博士後基金（2016M602327），廣東省農業農村廳和廣東省科技廳項目各1項，校沖補強項目1項，合計金額150萬元。到目前為止，共發表論文50多篇，其中SCI 收錄37篇，其中第一或通訊作者SCI文章7篇（ JCR一區4篇，JCR三區2篇，JCR四區1篇），中文收錄16篇，第一或通訊作者中文文章6篇。專利1篇。為廣東省“水産疫病監測與綜合防控共性關鍵技術研發創新團隊”專家。
主要研究興趣：
1. 水産動物疾病與健康養殖
2. 細菌耐藥性與抗生素替代品研發
3. 微生物功能因子鑒定與研究
4. 益生菌、益生元、抗菌肽、免疫添加劑研發
5. 養殖尾水處理與養殖工程
教育背景：
時 間 |
大 學 |
專 業 |
學 位 |
2015/8-2018/12 |
華中農業大學 |
獸醫方向 |
博士後 |
2009/9-2013/7 |
華中農業大學 |
水産養殖專業 |
博士 |
2005/9-2008/7 |
大連海洋大學 |
動物營養與飼料科學專業 |
碩士 |
1998/9-2000/7 |
煙台大學 |
淡水養殖專業 |
大專 |
工作經曆：
2019.1-至今 |
仲恺農業工程學院 |
太阳成集团tyc234cc |
水産系 |
2014.1-2018.12 |
山東省淡水漁業研究院 |
水産品資質檢定中心 |
藥殘檢測 |
2013.06-2013.12 |
中科院水生生物研究所 |
聶品研究員實驗室 |
黃杆菌胞外多糖相關研究
|
2008.8-2009.8 |
山東省淡水漁業研究院 |
水産病害研究 |
|
2002.4-2005.8 |
山東省淡水漁業研究院 |
水産養殖引種、繁育、養成、病害等相關工作
|
|
2000.7-2002.2 |
山東省膠州市國家級羅非魚良種場 |
水産養殖相關工作 |
近幾年主持項目情況：
（1）廣東省農業農村廳項目，水産疫病監測與綜合防控共性關鍵技術研發創新團隊專家，主持，35萬，2019/01-2023/12。
（2）2020年省級鄉村戰略專項資金（漁業發展項目）--廣東省水産養殖規範用藥項目，主持，50萬，2020/01-2021/12
（3）2019年仲恺農業工程學院國家與省基金培育項目，主持，6萬，2019/01-2020/12
（4）國家自然科學基金，青年基金項目編号為31602190，題目：MiR-155靶向踝蛋白抑制柱狀黃杆菌誘導EPC細胞凋亡的機制研究，主持，25萬，2017/01-2019/12。
（5）博士後自然科學基金，面上基金資助編号2016M602327，題目：miRNA-155調節柱狀黃杆菌誘導EPC細胞凋亡的機制研究，主持，5萬，2017/01-2018/12。
近幾年發表的主要論文：(以發表時間為序，*為通信作者,+為共同第一作者；JCR分區采用美國JCR系統)
英語文章：
1. Zhendong Qin, V. Sarath Babu, Hanzuo Lin, Yunjia Dai, Lijuan Zhao, Jungang Xie, Weiqiang Lin, Zaohe Wu, Jun Li*, Li Lin*. Antibacterial activity of erythrocyte from grass carp (Ctenopharyngodon idella) is associated with phagocytosis and reactive oxygen species generation. Fish Shellfish Immunol. 2019, accepted. SCI:3.02.（JCR 一區刊物）.
2. Muhammad Asim, V. Sarath Babu, Zhendong Qin, Lijuan Zhao, Jianguo Su, Jun Li, Jiagang Tu, Hongyan Kou*, Li Lin*. Inhibition of Cyclophilin A on the Replication of Red Spotted Grouper Nervous Necrosis Virus associates with multiple pro-inflammatory factors. Fish Shellfish Immunol. 2019, accepted. SCI:3.02.（JCR 一區刊物）.
3. Zhendong Qin, V. Sarath Babu, Hanzuo Lin, Yunjia Dai, Hongyan Kou, Liehuan Chen, Jun Li, Lijuan Zhao*, Li Lin*.The immune function of prophenoloxidase from red swamp crayfish (Procambarus clarkii) in response to bacterial infection. Fish Shellfish Immunol. 2019, accepted. SCI:3.02.（JCR 一區刊物）.
4. Farman Ullah Dawar, Sarath Babu V, Hongyan Kou, Zhendong Qin, Quanyuan Wan, Lijuan Zhao, Muhammad Nasir Khan Khattack, Jun Li, Jie Mei*, Li Lin*.The rag 2 gene of yellow catfish (Tachysurus fulvidraco) and its immune response against Edwardsiella ictaluri infection. Dev Comp Immunol, 2019,16;98:65-75.2019. SCI IF:2.815. （ JCR一區刊物）
5. Xiaodan Liu, Zhendong Qin, Sarath Babu V, Lijuan Zhao, Jun Li, Xiaojun Zhang, Li Lin*. Transcriptomic profiles of striped snakehead cells (SSN-1) infected with snakehead vesiculovirus (SHVV) identifying IFI35 as a positive factor for SHVV Replication. Fish Shellfish Immunol. 2019 Mar;86:46-52, SCI:3.02.（JCR 一區刊物）.
6. Meng Zhou, Quanyuan Wan, Sarath Babu V, Qiongju Qiu, Hongyan Kou, Chong Lin, Lijuan Zhao, Ling Yang, Jun Li, Yunmao Huang*, Li Lin*. Bacterial features in tilapia (Oreochromis niloticus) and environments in a goose-tilapia polyculture model. Aquaculture, 2018, 497: 313-319, SCI:2.57.（JCR Q1）.
7. Zhendong Qin+, V Sarath Babu+, Ningqiu Li, Tairan Fu, Jinquan Li, Lizhu Yi, Lijuan Zhao, Jun Li, Yang Zhou*, Li Lin*. Protective effects of chicken egg yolk immunoglobulins (IgY) against experimental Aeromonas hydrophila infection in Blunt snout bream (Megalobrama amblycephala) . Fish Shellfish Immunol. 2018 Jul;78:26-34. SCI:3.02.（JCR 一區刊物）.
8. Zhendong Qin, V. Sarath Babu, Quanyuan Wan, Meng Zhou, Risheng Liang, Asim Muhammad, Lijuan Zhao, Jun Li, Jiangfeng Lan* , Li Lin*. Transcriptome analysis of Pacific white shrimp (Litopenaeus vannamei) challenged by Vibrio parahaemolyticus reveals unique immune-related genes . Fish Shellfish Immunol. 2018 Jun;77:164-174. SCI:3.02.（JCR 一區刊物）.
9 .Xiaolei Wei, V. Sarath Babu, Li Lin, Yazhen Hu, Yulei Zhang, Xiaoling Liu, Jianguo Su, Jun Li, Lijuan Zhao*, Gailing Yuan*· Hepcidin protects grass carp (Ctenopharyngodon idellus) against Flavobacterium columnare infection via regulatin iron distribution and immune gene expression. Fish & Shellfish Immunology, 75: 274-283. April 2018.（JCR一區刊物）
10. Chi Zhang, Shuangshuang Feng, Wenting Zhang, Nan Chen, Abeer Hegazy,Wenjie Chen, Xueqin Liu, Lijuan Zhao, Jun Li, Li Lin* and Jiagang Tu*. MicroRNA miR-214 Inhibits Snakehead Vesiculovirus Replication by Promoting IFN-α Expression via Targeting Host Adenosine 5’-Monophosphate-Activated Protein Kinase. Frontiers in Immunology, 2017 Dec 11;8:1775. SCI: 6.4.（JCR 一區刊物）.
11. Farman Ullah Dawar, Xianqin Hu, Lijuan Zhao, Xingxing Dong, Yang Xiong, Meng Zhou, Rishen Liang, V Sarath Babu, Jun Li, Jie Mei*, Li Lin* .Transcriptomic analysis reveals differentially expressed genes and a unique apoptosis pathway in channel catfish ovary cells after infection with the channel catfish virus. Fish Shellfish Immunol. 2017 Sep 29;71:58-68. SCI:3.02.（JCR 一區刊物）.
12. Zhang Y, Zhao L*, Chen W, Huang Y, Yang L, Sarathbabu V, Wu Z, Li J, Nie P*, Lin L*. Complete genome sequence analysis of the fish pathogen Flavobacterium columnare provides insights into antibiotic resistance and pathogenicity related genes. Microb Pathog. 2017 Sep 1;111:203-211 SCI : 2.0. （JCR 三區刊物）
13. Lin Q, Fu X, Li N, Wan Q, Chen W, Huang Y, Huang Z, Li J, Zhao L*, Lin L*. Co-infections of infectious spleen and kidney necrosis virus and Siniperca chuatsi rhabdovirus in Chinese perch (Siniperca chuatsi). Microb Pathog. 2017 Sep 7;111:422-430. SCI : 2.0. （JCR 三區刊物）
14. Lindan Sun+, Jiagang Tu+, Lizhu Yi, Wenjie Chen, Lijuan Zhao, Yunmao Huang, Rishen Liang, Jun Li, Meng Zhou*, Li Lin*. Pathogenicity of snakehead vesiculovirus in rice field eels (Monopterus albus). Microb Pathog. 2017 Sep;110:578-585. SCI : 2.0. （JCR 三區刊物）
15. Chi Zhang, Lizhu Yi, Shuangshuang Feng, Xueqin Liu, Jianguo Su, Li Lin, Jiagang Tu*. MicroRNA miR-214 inhibits snakehead vesiculovirus (SHVV) replication by targeting the coding regions of viral N and P. Journal of General Virology, 2017 Jul;98(7):1611-1619. SCI IF :3.2. （JCR 三區刊物）
16.Jiali Jin+, Yao Wang+, Zhixin Wu, Abeer Hergazy, Jiangfeng Lan, Lijuan Zhao， Xiaoling Liu, Nan Chen*, Li Lin*.Transcriptomic analysis of liver from grass carp (Ctenopharyngodon idellus) exposed to high environmental ammonia reveals the activation of antioxidant and apoptosis pathways. Fish Shellfish Immunol. 2017 Apr;63:444-451 SCI:3.02.（JCR 一區刊物）
17. Wenjie Chen, Lizhu Yi, Shuangshuang Feng, Lijuan Zhao, Jun Li, Meng Zhou, Rishen Liang, Na Gu, Zaohe Wu, Jiagang Tu*, Li Lin*. Characterization of microRNAs in orange-spotted grouper (Epinephelus coioides) fin cells upon red-spotted grouper nervous necrosis virus infection.Fish Shellfish Immunol. 2017, 63:228-236. SCI:3.02.（JCR 一區刊物）
18. Ze Zhang, Angen Yu, Jiangfeng Lan, Hua Zhang , Minqiang Hu, Jiewei Cheng, Lijuan Zhao, Li Lin*, Shun Wei*. GapA, a potential vaccine candidate antigen against Streptococcus agalactiae in Nile tilapia (Oreochromis niloticus). Fish Shellfish Immunol. 2017, 63:255-260.SCI:3.02.（JCR 一區刊物）
19. Yun-Jia Dai, Kai-Min Hui, Ying-Hao Zhang, Yan Liu, Yu-Qing Wang, Li-Juan Zhao, Li Lin, Lian-Qin Chai, Shun Wei, Jiangfeng Lan. Three STATs are involved in the regulation of the expression of antimicrobial peptides in the triangle sail mussel, Hyriopsis cumingii. Fish Shellfish Immunol. 2017 Apr;63:181-188. SCI:3.02.（JCR 一區刊物）
20. Xiaozhe Fu, Xianqin Hu, Ningqiu Li*, Feifei Zheng, Xingxing Dong, Jing Duan, Qiang Lin, Jiagang Tu, Lijuan Zhao, Zhibin Huang, Jianguo Su, Li Lin*. Glutamine and glutaminolysis are required for efficient replication of infectious spleen and kidney necrosis virus in Chinese perch brain cells. Oncotarget, 2017, Vol. 8, (No. 2), pp: 2400-2412. SCI :5.08 (JCR 一區刊物).
21. Farman Ullah Dawar, Junjie Wu, Lijuan Zhao, Muhammad Nasir Khan Khattak, Jie Mei*, Li Lin*. Updates in understanding the role of cyclophilin A in leukocyte chemotaxis. Journal of Leukocytes Biology. 2017 Apr;101(4):823-826 ; SCI IF :4.16. （JCR 一區刊物）
22. Yunjia Dai, Yuqing Wang, Yinghao Zhang,Yan Liu, Jinquan Li, Shun Wei, Lijuan Zhao,Yongcan Zhou, Li Lin*, Jiangfeng Lan*. The role of ficolin-like protein (PcFLP1) in the antibacterial immunity of red swamp crayfish (Procambarus clarkii). Molecular Immunology. 2016 Nov 23;81:26-34. SCI:3.23(JCR三區刊物)
23. Muhammad Asim, Sanjie Jiang, Lizhu Yi, Wenjie Chen, Lindan Sun, Lijuan Zhao, Muhammad Nasir Khan Khattak, Jiagang Tu*, Li Lin*. Glutamine is required for red-spotted grouper nervous necrosis virus replication via replenishing the tricarboxylic acid cycle. Virus Research. 2016, 227:245-248. SCI :2.7（JCR 三區刊物）
24. Jiangfeng lan, Lijuan Zhao, Shun Wei, Yuan Wang, Li Lin, Xincang Li. PcToll2 positively regulates the expression of antimicrobial peptides by promoting PcATF4 translocation into the nucleus. Fish Shellfish Immunol. 2016 Sep 10;58:59-66. SCI:3.02.（JCR 一區刊物）
25. Lindan Sun, Lizhu Yi, Chi Zhang, Xiaodan Liu, Shuangshuang Feng, Wenjie Chen, Jiangfeng Lan, Lijuan Zhao, Jiagang Tu*, Li Lin*. Glutamine was required for snakehead fish vesiculovirus (SHVV) propagation via replenishing the tricarboxylic acid cycle. Journal of General Virology, 2016 Nov;97(11):2849-2855. SCI IF :3.2（ JCR三區刊物）
26. Jiang-Feng Lan, Shun Wei, Yu-Qing Wang, Yun-Jia Dai, Jia-Gang Tu, Li-Juan Zhao, Xin-Cang Li, Qi-Wei Qin, Nan Chen*, Li Lin*. PcToll3 positively regulates the expression of antimicrobial peptides by promoting PcDorsal translocation into nucleus in red swamp crayfish, Procambarus clarkii. Fish and Shellfish Immunology, 2016, 57:17-24. SCI:3.02.（JCR 一區刊物）
27. Lijuan Zhao+, Jiagang Tu+, Yulei Zhang, Jinfu Wang, Ling Yang, Weimin Wang, Zaohe Wu, Qinglei Meng*, Li Lin*.Transcriptomic analysis of the head kidney of Topmouth culter (Culter alburnus) infected with Flavobacterium columnare with an emphasis on phagosome pathway. Fish and Shellfish Immunology, 2016 Oct;57:413-8. SCI:3.02.（JCR 一區刊物）
28. Yao Wang, Nan Chen, Abeer M. Hegazy, Xiaodan Liu, Zhixin Wu , Xueqin Liu, Lijuan Zhao, Qiwei Qin, Jiangfeng Lan*, Li Lin*. Autophagy induced by Snakehead fish vesiculovirus inhibited its replication in SSN-1 cell line. Fish and Shellfish Immunology, 2016, 55:415-422. SCI:3.02.（JCR 一區刊物）
29. Zhao LL, Wang YQ, Dai YJ, Zhao LJ, Qin Q, Lin L, Ren Q, Lan JF. A novel C-type lectin with four CRDs is involved in the regulation of antimicrobial peptide gene expression in Hyriopsis cumingii. Fish and Shellfish Immunology, 2016, 55:339-347. SCI:3.02.（JCR 一區刊物）
30. Yunjia Dai, Yuqing Wang, Lingling Zhao, Zhendong Qin, Junfa Yuan, Qiwei Qin, Li Lin*, Jiangfeng Lan*. A novel L-type lectin was required for the multiplication of WSSV in red swamp crayfish (Procambarus clakii). Fish and Shellfish Immunology, 2016, 55:48-55. SCI : 3.02.（JCR 一區刊物）
31. Jiagang Tu+, Wenjie Chen+, Xiaozhe Fu, Qiang Lin, Ouqin Chang, Lijuan Zhao,Jiangfeng Lan*, Ningqiu Li *, Li Lin *.Susceptibility of Chinese perch brain (CPB) cell and Mandarin fish to Red-spotted grouper nervous necrosis virus (RGNNV) infection. Int J Mol Sci. 2016, May 19;17(5). pii: E740. doi: 10.3390/ijms17050740. SCI IF : 3.2（ JCR四區刊物）
32. Zhao L, Lu H, Meng Q, Wang J, Wang W, Yang L*, Lin L*. Profilings of MicroRNAs in the·· Liver of Common Carp (Cyprinus carpio) Infected with Flavobacterium columnare. Int J Mol Sci. 2016 Apr 15;17(4). pii: E566. doi: 10.3390/ijms17040566. SCI IF : 3.2（ JCR四區刊物）
33.Xiaodan Liu, Jiagang Tu, Junfa Yuan，Xueqin Liu, Lijuan Zhao，Farman Ullah Dawar，Muhammad Nasir Khan Khattak，Abeer M Hegazy，Nan Chen，Vikram N Vakharia, Li Lin*. Identification and Characterization of MicroRNAs in Snakehead Fish Cell Line upon Snakehead Fish Vesiculovirus Infection. International Journal of Molecular Sciences，2016，17(2)：12-16. SCI IF : 3.2（ JCR四區刊物）
34. Feifei Zheng, Muhammad Asim, Jiangfeng Lan, Lijuan Zhao, Shun Wei, Nan Chen, Xiaolin Liu, Yang Zhou*, Li Lin*.Molecular Cloning and Functional Characterization of Mannose Receptor in Zebra Fish (Danio rerio) during Infection with Aeromonas Sobria. International Journal of Molecular Sciences, 2015 ,16(5):10997-1012. SCI IF : 2.862（ JCR四區刊物）
35. Xianqin Hu, Xiaozhe Fu, Ningqiu Li*, Xingxing Dong,Lijuan Zhao,Jiangfeng Lan,Wei Ji,Weidong Zhou, Taoshan Ai, Shuqin Wu, Li Lin*. Transcriptomic analysis of Mandarin fish brain cells infected with infectious spleen and kidney necrosis virus with an emphasis on retinoic acid-inducible gene 1-like receptors and apoptosis pathways. Fish and Shellfish Immunology, 2015, 45 : 619-629. SCI IF: 2.674..（ JCR一區刊物）
36. Li Juan Zhao，Jin Fang Lu，P. Nie, Ai Hua Li, Bang Xi Xiong, Hai Xia Xie. Roles of plasmid-encoded proteins, EseH, EseI and EscD in invasion, replication and virulence of Edwardsiella ictaluri. Veterinary Microbiology, 2013, 166, 233–241. （JCR一區刊物）
37. Shan Nan Chen, Bei Huang, Xiao Wen Zhang, Ye Li, Li Juan Zhao, Nan Li, Qian Gao, P. Nie. IFN-c and its receptors in a reptile reveal the evolutionary conservation of type II IFNs in vertebrates. Developmental and Comparative Immunology, 2013, 41, 587–596. （JCR二區刊物）
· 中文刊物：
1. 資英娟,秦真東，詹凡玢，謝昊堃,張瀚雲，黎 烽，李濱， 趙皓翰，謝遠崧，趙麗娟*，林蠡*.一株保護草魚腸道和改善水質的枯草芽孢杆菌的分離鑒定及全基因組分析.水産學報, 2020, 44(7): 1173−1186.
2. 王玟秀，秦真東，Sarath Bubu V，周萌，梁日深，莫金鳳，吳竈和，張軒, 趙麗娟*，林蠡*. 抑制氣呼吸導緻大鱗副泥鳅 (Paramisgurnus dabryanus) 主要呼吸器官的組織病理變化觀察. 水産學報, （已接收）
3. 李嘉波，秦真東，趙麗娟，劉志剛，可小麗，吳竈和，劉小玲，盧邁新*，林蠡*. 羅非魚湖病毒對尼羅羅非魚(Oreochromis niloticus）和E-11細胞的感染研究. 水産學報, （已接收）
4. 何昕，秦真東，張凱，梁日深，楊森，伍劍标, 趙麗娟*，林蠡*. 蘇丹魚（Leptobarbus hoevenii）甘露糖受體的基因克隆表達和免疫特性研究. 水産學報, 2020, 44(3): 378−390
5. 蘇國茂，秦真東，李嘉波，周萌，莫金鳳，張凱，梁日深，吳竈和，趙麗娟*，林蠡*. 羅湖病毒核蛋白的克隆表達、抗體制備及其組織分布研究. 水産學報, 2020, 44(2): 276−288
6. 盧志傑，葉成凱，Sarath Babu V，張曉君，劉曉丹，趙麗娟，潘淦*，林蠡*.羅氏沼蝦谷氨酰胺合成酶基因的克隆與表達. 水産學報, 2019,43(03):549-562.
7. 葉成凱，盧志傑，Sarath Babu V，張曉君，劉曉丹，趙麗娟，潘凎*，林 蠡*.羅氏沼蝦幾丁質酶3B基因的克隆及其在蛻皮周期中的表達. 水産學報, 2019(04):751-762.
8. 付泰然，劉廣鑫，萬全元，吳霆，趙麗娟，楊靈*，林蠡*. 基于棧式自編碼BP神經網絡預測水體亞硝态氮濃度模型. 水産學報, 2019(04):958-967.
9. 馮燕,秦真東,代雲佳,張玉蕾,劉小玲,周洋,蘭江風,趙麗娟*,林蠡*.草魚核因子E2相關因子2基因克隆分析及其對呼吸爆發的調控作用[J].水産學報,2018,42(02):161-177
10. 段靜,劉廣鑫,董晏君,周洋,李錦铨,劉小玲,周萌,梁日深,趙麗娟*,林蠡*.解澱粉芽孢杆菌HZ-1510殼聚糖酶基因的克隆、重組表達及其活性[J].水産學報,2017,41(10):1552-1561.
11. 林蠡,趙麗娟,陳文捷.采用三套環理論指導水産疾病高效防控，科學養魚，2016,32(1):59-60.
12. 胡先勤，付小哲，董星星，塗加鋼，趙麗娟，林強，李甯求，林蠡*. 鳜親環蛋白A在傳染性脾腎壞死病毒增殖中的作用.水産學報，2016，40(1):100-109
13. 張玉蕾，趙麗娟，周偉東,艾桃山,林蠡*.黃颡魚源柱狀黃杆菌對鳜魚的緻病性研究. 華中農業大學學報.2016.35:83-39.
14. 王吉橋，趙麗娟，姜玉生，張劍誠，王錫榮.飼料中不同脂肪酸搭配對仿刺參幼參生長和體組分的影響.漁業科學進展,2009.30: 62-73.
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· 專利：
1. 一種高緻病性嗜水氣單胞菌及應用，發明專利，發明人：周洋、李錦铨、林蠡、趙麗娟、王小紅、李智、喻蔚，授權時間：2018年5月8日，（ZL201610242186.0）
